diff --git a/lang/python/python-cryptography/Makefile b/lang/python/python-cryptography/Makefile
index 7881634f3c..000b983bb7 100644
--- a/lang/python/python-cryptography/Makefile
+++ b/lang/python/python-cryptography/Makefile
@@ -8,11 +8,11 @@
 include $(TOPDIR)/rules.mk
 
 PKG_NAME:=python-cryptography
-PKG_VERSION:=48.0.0
+PKG_VERSION:=50.0.2
 PKG_RELEASE:=1
 
 PYPI_NAME:=cryptography
-PKG_HASH:=5c3932f4436d1cccb036cb0eaef46e6e2db91035166f1ad6505c3c9d5a635920
+PKG_HASH:=7b46165bb56eb4704e2eaaf86f3c940d19154535d9b0ca7d6d590b04060e00d5
 
 PKG_LICENSE:=Apache-2.0 BSD-3-Clause
 PKG_LICENSE_FILES:=LICENSE.APACHE LICENSE.BSD
diff --git a/lang/python/python-cryptography/patches/001-cffi-build-rs-derive-include-from-pyo3-cross.patch b/lang/python/python-cryptography/patches/001-cffi-build-rs-derive-include-from-pyo3-cross.patch
deleted file mode 100644
index ebff1d70ee..0000000000
--- a/lang/python/python-cryptography/patches/001-cffi-build-rs-derive-include-from-pyo3-cross.patch
+++ /dev/null
@@ -1,93 +0,0 @@
-From 5d072cb2a68506445844112e95b732c4287f39a0 Mon Sep 17 00:00:00 2001
-From: Alexandru Ardelean <ardeleanalex@gmail.com>
-Date: Wed, 27 May 2026 14:28:58 +0300
-Subject: [PATCH] cffi: derive Python include dir from PYO3_CROSS_LIB_DIR when
- cross-compiling (#14904)
-
-When cross-compiling, ``cryptography-cffi/build.rs`` queries the host
-interpreter via ``setuptools.command.build_ext.build_ext.include_dirs``
-and feeds the result into ``cc-rs`` as ``-I /usr/include/python3.X``.
-On hosts that happen to ship Python development headers for the same
-3.X line as the target (e.g. an Arch Linux build host with Python 3.14
-installed), the host headers leak into the cross build and the target
-compiler aborts with::
-
-    /usr/include/python3.14/pyport.h:429:2: error: #error "LONG_BIT
-    definition appears wrong for platform (bad gcc/glibc config?)."
-
-``PYO3_CROSS_LIB_DIR`` is the documented PyO3 cross-compile signal and
-points at the target's libpython directory. When it is set, derive the
-matching Python include dir from it (``<prefix>/include/<py_ver>``) and
-skip the host setuptools probe entirely. Native builds keep the
-existing setuptools-based behaviour, so this is a no-op outside of
-PyO3-style cross builds.
-
-This is consistent with the existing ``PYO3_PYTHON`` handling in the
-same file: cryptography-cffi already respects PyO3's cross-compile
-environment for picking the interpreter, and this extends that to the
-matching header directory.
-
-Signed-off-by: Alexandru Ardelean <ardeleanalex@gmail.com>
-
-[OpenWrt: dropped the CHANGELOG.rst hunk — the 48.0.0 source tarball
-does not yet carry the post-48.0.0 "unreleased" section the upstream
-hunk targets. Drop this patch on next bump once the upstream change is
-in a tagged release.]
-Signed-off-by: Alexandru Ardelean <alex@shruggie.ro>
----
- src/rust/cryptography-cffi/build.rs | 44 ++++++++++++++++++++++-------
- 1 file changed, 34 insertions(+), 10 deletions(-)
-
---- a/src/rust/cryptography-cffi/build.rs
-+++ b/src/rust/cryptography-cffi/build.rs
-@@ -56,16 +56,40 @@ fn main() {
-     )
-     .unwrap();
-     println!("cargo:rustc-cfg=python_implementation=\"{python_impl}\"");
--    let python_includes = run_python_script(
--        &python,
--        "import os; \
--         import setuptools.dist; \
--         import setuptools.command.build_ext; \
--         b = setuptools.command.build_ext.build_ext(setuptools.dist.Distribution()); \
--         b.finalize_options(); \
--         print(os.pathsep.join(b.include_dirs), end='')",
--    )
--    .unwrap();
-+    println!("cargo:rerun-if-env-changed=PYO3_CROSS_LIB_DIR");
-+    // When cross-compiling, PyO3 expects the build system to point
-+    // PYO3_CROSS_LIB_DIR at the target's libpython directory. Derive the
-+    // matching include dir from it instead of querying the host
-+    // interpreter's setuptools, which returns host headers (e.g.
-+    // /usr/include/python3.x) and breaks the cross build whenever the host
-+    // happens to have same-version Python development headers installed.
-+    let python_includes = if let Ok(lib_dir) = env::var("PYO3_CROSS_LIB_DIR") {
-+        let lib = Path::new(&lib_dir);
-+        let py_ver = lib
-+            .file_name()
-+            .and_then(|s| s.to_str())
-+            .unwrap_or("python3");
-+        let prefix = lib
-+            .parent()
-+            .and_then(|p| p.parent())
-+            .expect("PYO3_CROSS_LIB_DIR has unexpected layout");
-+        prefix
-+            .join("include")
-+            .join(py_ver)
-+            .to_string_lossy()
-+            .into_owned()
-+    } else {
-+        run_python_script(
-+            &python,
-+            "import os; \
-+             import setuptools.dist; \
-+             import setuptools.command.build_ext; \
-+             b = setuptools.command.build_ext.build_ext(setuptools.dist.Distribution()); \
-+             b.finalize_options(); \
-+             print(os.pathsep.join(b.include_dirs), end='')",
-+        )
-+        .unwrap()
-+    };
-     let openssl_c = Path::new(&out_dir).join("_openssl.c");
- 
-     let mut build = cc::Build::new();